HORDB

ID: hor002914
Uniprot ID: P10776
Protein name: Neuroparsin-B
Gene name: NA
Organism: Locusta migratoria (Migratory locust)
Family: NA
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Locusta (genus), Oedipodinae (subfamily), Acrididae (family), Acridoidea (superfamily), Acridomorpha, Acrididea (infraorder), Caelifera (suborder), Orthoptera (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: NA

Sequence: SCEGANCVVDLTRCEYGDVTDFFGRKVCAKGPGDKCGGPYELHGKCGVGMDCRCGLCSGCSLHNLQCFFFEGGLPSSC
Length: 78(30-107)
Propeptide: MKATAALVAATLLLAVTLFHRAERNPISRSCEGANCVVDLTRCEYGDVTDFFGRKVCAKGPGDKCGGPYELHGKCGVGMDCRCGLCSGCSLHNLQCFFFEGGLPSSC
Signal peptide: MKATAALVAATLLLAVTLFHRA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: inhibit the effects of juvenile hormone, stimulate fluid reabsorption of isolated recta and induces an increase in hemolymph lipid and trehalose levels
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002914_AF2.pdb

hor002914_ESM.pdb

Mass:	957101	Formula:	C344H528N98O109S13
Absent amino acids:	IW	Common amino acids:	G
pI:	5.59	Basic residues:	9
Polar residues:	37	Hydrophobic residues:	18
Hydrophobicity:	-3.33	Boman Index:	-8925
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	51.15
Instability Index:	1981.79	Extinction Coefficient cystines:	3730
Absorbance 280nm:	48.44